chapelhillmensch
Bitchin' Camaro
This is not rhetorical,I am serious.
Salvia Potency
By mass, salvinorin A "is the most potent naturally occurring hallucinogen."[57] It is active at doses as low as 200 µg.[24][53][57] Synthetic chemicals, such as LSD (active at 2030 µg doses), can be more potent.[58] Research has shown that salvinorin A is a potent and selective κ-Opioid (kappa-Opioid) receptor agonist.[53][59] It has been reported that the effects of salvinorin A in mice are blocked by κ-Opioid receptor antagonists.[11] However, it is an even more potent D2 receptor partial agonist, and it is likely this action plays a significant role in its effects as well.[12] Salvinorin A has no actions at the 5-HT2A serotonin receptor, the principal molecular target responsible for the actions of 'classic' hallucinogens, such as mescaline and LSD, nor is it known to have affinity for any other sites to date.
Great... not only are the youngin's Texting while driving but the are smoking legal hallucinogen's as well.
God whatever happen to the good old days in Telluride smoking weed shrooming ' and watching Prince's Rasberry Beret video in our cabin below the Spiral Stairs run....
Oh well we all get old
Happy Holidays-
Salvia Potency
By mass, salvinorin A "is the most potent naturally occurring hallucinogen."[57] It is active at doses as low as 200 µg.[24][53][57] Synthetic chemicals, such as LSD (active at 2030 µg doses), can be more potent.[58] Research has shown that salvinorin A is a potent and selective κ-Opioid (kappa-Opioid) receptor agonist.[53][59] It has been reported that the effects of salvinorin A in mice are blocked by κ-Opioid receptor antagonists.[11] However, it is an even more potent D2 receptor partial agonist, and it is likely this action plays a significant role in its effects as well.[12] Salvinorin A has no actions at the 5-HT2A serotonin receptor, the principal molecular target responsible for the actions of 'classic' hallucinogens, such as mescaline and LSD, nor is it known to have affinity for any other sites to date.
Great... not only are the youngin's Texting while driving but the are smoking legal hallucinogen's as well.
God whatever happen to the good old days in Telluride smoking weed shrooming ' and watching Prince's Rasberry Beret video in our cabin below the Spiral Stairs run....
Oh well we all get old
Happy Holidays-
