Diabetes breakthrough!

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Sandie S-R

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Interesting new article on Diabetes discovery

Diabetes breakthrough! Toronto scientists cure disease in mice
Tom Blackwell, National Post
Published: Friday, December 15, 2006

In a discovery that has stunned even those behind it, scientists at
a Toronto hospital say they have proof the body's nervous system
helps trigger diabetes, opening the door to a potential near-cure of
the disease that affects millions of Canadians.

Diabetic mice became healthy virtually overnight after researchers
injected a substance to counteract the effect of malfunctioning pain
neurons in the pancreas.

"I couldn't believe it," said Dr. Michael Salter, a pain expert at
the Hospital for Sick Children and one of the scientists. "Mice with
diabetes suddenly didn't have diabetes any more."

The researchers caution they have yet to confirm their findings in
people, but say they expect results from human studies within a year
or so. Any treatment that may emerge to help at least some patients
would likely be years away from hitting the market.

But the excitement of the team from Sick Kids, whose work is being
published today in the journal Cell, is almost palpable.

"I've never seen anything like it," said Dr. Hans Michael Dosch, an
immunologist at the hospital and a leader of the studies. "In my
career, this is unique."

Their conclusions upset conventional wisdom that Type 1 diabetes,
the most serious form of the illness that typically first appears in
childhood, was solely caused by auto-immune responses -- the body's
immune system turning on itself.

They also conclude that there are far more similarities than
previously thought between Type 1 and Type 2 diabetes, and that
nerves likely play a role in other chronic inflammatory conditions,
such as asthma and Crohn's disease.

The "paradigm-changing" study opens "a novel, exciting door to
address one of the diseases with large societal impact," said Dr.
Christian Stohler, a leading U.S. pain specialist and dean of
dentistry at the University of Maryland, who has reviewed the work.

"The treatment and diagnosis of neuropathic diseases is poised to
take a dramatic leap forward because of the impressive research."

About two million Canadians suffer from diabetes, 10% of them with
Type 1, contributing to 41,000 deaths a year.

Insulin replacement therapy is the only treatment of Type 1, and
cannot prevent many of the side effects, from heart attacks to
kidney failure.

In Type 1 diabetes, the pancreas does not produce enough insulin to
shift glucose into the cells that need it. In Type 2 diabetes, the
insulin that is produced is not used effectively -- something called
insulin resistance -- also resulting in poor absorption of glucose.

The problems stem partly from inflammation -- and eventual death --
of insulin-producing islet cells in the pancreas.

Dr. Dosch had concluded in a 1999 paper that there were surprising
similarities between diabetes and multiple sclerosis, a central
nervous system disease. His interest was also piqued by the presence
around the insulin-producing islets of an "enormous" number of
nerves, pain neurons primarily used to signal the brain that tissue
has been damaged.

Suspecting a link between the nerves and diabetes, he and Dr. Salter
used an old experimental trick -- injecting capsaicin, the active
ingredient in hot chili peppers, to kill the pancreatic sensory
nerves in mice that had an equivalent of Type 1 diabetes.

"Then we had the biggest shock of our lives," Dr. Dosch said. Almost
immediately, the islets began producing insulin normally "It was a
shock ? really out of left field, because nothing in the literature
was saying anything about this."

It turns out the nerves secrete neuropeptides that are instrumental
in the proper functioning of the islets. Further study by the team,
which also involved the University of Calgary and the Jackson
Laboratory in Maine, found that the nerves in diabetic mice were
releasing too little of the neuropeptides, resulting in a "vicious
cycle" of stress on the islets.

So next they injected the neuropeptide "substance P" in the
pancreases of diabetic mice, a demanding task given the tiny size of
the rodent organs. The results were dramatic.

The islet inflammation cleared up and the diabetes was gone. Some
have remained in that state for as long as four months, with just
one injection.

They also discovered that their treatments curbed the insulin
resistance that is the hallmark of Type 2 diabetes, and that insulin
resistance is a major factor in Type 1 diabetes, suggesting the two
illnesses are quite similar.

While pain scientists have been receptive to the research,
immunologists have voiced skepticism at the idea of the nervous
system playing such a major role in the disease. Editors of Cell put
the Toronto researchers through vigorous review to prove the
validity of their conclusions, though an editorial in the
publication gives a positive review of the work.

"It will no doubt cause a great deal of consternation, " said Dr.
Salter about his paper.

The researchers are now setting out to confirm that the connection
between sensory nerves and diabetes holds true in humans. If it
does, they will see if their treatments have the same effects on
people as they did on mice.

Nothing is for sure, but "there is a great deal of promise," Dr.
Salter said.
 

NFA

Results STILL NOT typical
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A stunning and welcome development. Obviously this is too early to be too hopeful, but come cautious encouragement is warrented. Thank goodness for researchers willing to look outside common assumpsions on this one.
 

Green Eyed Fairy

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I was married to a type I for 14 years and have three children by him. This is indeed exciting news since I have to worry about my children one day acquiring diabetes. I have to wonder, though, which type of diabetic will benefit from this and when? My ex's pancreas totally stopped working at age 12- that makes me wonder if there would be no way to correct a pancreas malfunction since it doesnt work, period.
 

Fairia

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It really does look promising. And if their research is true, then it's a scientific breakthrough in medicine to learn and study. And it looks like hot chili peppers actually have health benefits some never thought of.
 

missaf

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This is very interesting. Vietnam Veterans exposed to Agent Orange have a wide range of symptoms, but most notably among them are Type I Diabetes, radiculopathy (Painful nerves), and neuropathy (loss of feeling). If these are all indeed nervous system issues, that means many of their children will be eligible for benefits, too.
 

Renaissance Man

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Absolutely amazing . . . I just hope the part of the medical community that has "serious doubts" will become open to the possibility that they don't have all the answers and that someone out there may actually have stumbled on a cure. While it's good to have some healthy doubt as to prevent snake oil peddlers, I always hate hearing about members of the medical community balking at possibilities.

Sometimes, ya just gotta wonder about arrogance & greed in the medical and pharmaceutical world.....how many times have they stifled breakthroughs or cures?

My father's Type II and diabetes is present in my family history. If this is a breakthrough, I say, bring it on! Kudos to that research team!
 

Sandie S-R

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Absolutely amazing . . . I just hope the part of the medical community that has "serious doubts" will become open to the possibility that they don't have all the answers and that someone out there may actually have stumbled on a cure. While it's good to have some healthy doubt as to prevent snake oil peddlers, I always hate hearing about members of the medical community balking at possibilities.

Sometimes, ya just gotta wonder about arrogance & greed in the medical and pharmaceutical world.....how many times have they stifled breakthroughs or cures?

My father's Type II and diabetes is present in my family history. If this is a breakthrough, I say, bring it on! Kudos to that research team!

So true about the greed thing. That thought occurred to me as well. If diabetes can be cured with something like capsacin, then the drug companies may miss out on lots of money, and will they make a big stink?? Let's hope that curing the disease is more important that the money the cure can generate.

Hey John! Good to see you around. Hope you are well, and having a wonderful holiday season!!!

Big hugs to you!!
 

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