Manuel Uribe, who hasn't left his bed in six years, married his longtime girlfriend Claudia Solis on Sunday in northern Mexico.
Wearing a white silk shirt with a sheet wrapped around his legs, Mr Uribe smiled as Miss Solis, 38, walked down a flight of stairs wearing a strapless ivory dress, a tiara and hot-pink lipstick.
He later broke into tears as a notary declared the couple husband and wife in a civil ceremony attended by more than 400 guests. For the traditional first dance as newlyweds, the couple held hands and swayed to a romantic ballad.
A band playing the popular local norteño music played at the reception, which featured a banquet of meat and buttered vegetables.
Mr Uribe's mother, Orquedia Garza, said the groom did not eat any of the five-tiered wedding cake.
"He didn't break his diet," she told The Associated Press. "His doctors are here and they are watching him very closely."
The wedding, which was closed to most media, will be featured in an upcoming Discovery Channel documentary on Mr Uribe, the 43-year-old former mechanic said.
"I have a wife and will form a new family and live a happy life," he told hordes of reporters earlier as they followed him through the streets of Monterrey.
A flatbed truck was brought in to tow his custom-made bed decorated with a canopy, flowers and gold-trimmed bows to the wedding at a local event hall. Two police patrol cars escorted him ahead of a long line of traffic.
In 2006, Mr Uribe weighed 87st 12lbs (560kg), earning him the Guinness World Record as the world's heaviest man.
He has since shed about 550lbs (250kg) with the help of Miss Solis, who he met four years ago. He now weighs about 48st and said he is now aiming for a new title of world's greatest weight loser.
